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Objective To investigate the factors affecting the stability of the volatile oil extracted fromYinqiaosan Decoction.Methods The main chemical compositions and the extraction repetitiveness of the compound volatile oil were determined by GC-MS, and the stability of multiple extracted volatile oil was studied. Absorbance of the compound volatile oil was used as the evaluation index, and the factors affecting the stability of the of the compound volatile oil were investigated, such as illumination, temperatures and pH values of volatile oil solution and metal ions.Results The results of the GC-MS chromatograph indicated that the main chemical compositions of the compound volatile oil extracted fromYinqiaosan Decoction twice were the same. The results of the stability of the volatile oil showed that the preservation temperature and illumination affected the stability of the volatile oil to a certain extent. The absorbance values of the compound volatile oil changed slowly when it was stored at a relatively low temperature (4℃) and shielded from light, and it was less stable when stored in normal temperature and under illumination. Meanwhile, the absorbance of the compound volatile oil changed quickly in acid or alkaline solutions and was in instability. The metal ions, such as Cu2+ and Fe3+, have chemical reactions with the compositions of the compound volatile oil and there was a big change in the UV-Vis spectrum of the compound volatile oils.Conclusion The compound volatile oil should be stored at a relatively low temperature (4℃) and shielded from light. At the same time, it should be stored avoiding acids, alkaline and the metal ions, such as Cu2+ and Fe3+, to guarantee its stability. This study provides a reference for the preservation conditions and the preparation conditions of the compound volatile oil extracted fromYinqiaosan Decoction.
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Objective To observe and compare the clinical efifcacy of buyanghuanwu decotion combined with aspirin in treatment of aspirin resistance when transient ischemic attack(TIA). Methods 80 patients with TIA from September 2010 to October 2013 in Affiliated Hospital of Weifang Medical College were selected according to the standards and divided into two groups, with 40 cases in each group. Experimental group were orally administered with buyanghuanwu decotion and aspirin. Control group were orally administered with clopidogrel and aspirin. The levels of arachidonic acid (AA) and adenosine diphosphate (ADP) before therapy and in the 60 th and 90 th treatment day were detected by turbidimetry, respectively. Follow-up studies were performed to observe the recurrence numbers of TIA, cerebral infarction cases and adverse events, such as mucocutaneous hemorrhage and hemafacia in two groups during therapy. Results The levels of AA and ADP were decreased constantly with the therapy time in both two groups. The levels of ADP and AA in experimental group before therapy and in the 60 th and 90 th treatment day were not signiifcantly different from those in control group. No signiifcant differences of reoccurrence rate and the cerebral infarction rate were found between the two groups. However, there was statically signiifcant difference in the occurrence of adverse events between the two groups (P<0.05). Conclusion The clinical efifcacy of the combined treatment of buyanghuanwu decotion with aspirin shows no signiifcant difference with the combined treatment of clopidogrel and aspirin, but with lower incidence rate of adverse events.
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OBJECTIVE@#To investigate the clinical outcomes of facial nerve decompression via transmastoid, extra labyrinthine,subtemporal approach for management of facial paralysis in temporal bone fracture.@*METHOD@#Twenty-six cases of traumatic facial paralysis (House-Brackmann grade III-V) hospitalized between January 2006 and April 2008 received facial nerve decompression surgery. There were 4 patients diagnosed as House-Braekmann Grade III, 12 as Grade V in and 10 as Grade VI. The preoperative mean air conduction threshold was 52 dB in 16 cases with longitudinal temporal bone fracture and serious sensorineural heating loss in 10 cases with transverse temporal bone fracture. The fracture lines were detected in 13 cases by temporal bone axial CT scans and ossicular disruption could be determined in 9 cases by virtual endoscopy. The geniculate ganglion,the tympanic and mastoid segment of the facial nerve displayed an irregular morphology in curved planar reformation images of the facial nerve canal.@*RESULT@#All cases had primary healing and no complication occurred. At following-up times ranging from 0.5 to 3 years (average 1.2 years), facial nerve function recovered to House-Brackmann Grades I in 15, II in 6, III in 5. Overall air conduction pure tone averages improved 33 dB.@*CONCLUSION@#Facial nerve decompression with rebuilding of ossicular chain through transmastoid, extralabyrinthine, subtemporal approach is a good approach for the treatment of facial paralysis in temporal bone fracture.
Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , Decompression, Surgical , Methods , Facial Paralysis , General Surgery , Fractures, Bone , General Surgery , Mastoid , General Surgery , Otologic Surgical Procedures , Temporal Bone , General SurgeryABSTRACT
OBJECTIVE:To determine compatible stability of Fructose injection mixed with 5 kinds of drugs respectively,i.e. cefradine for injection,ribavirin injection,aciclovir for injection and levofloxacin hydrochloride for injection,penicillin for injection. METHODS:UV spectrophotometry was applied to investigate appearance,pH value,content and insoluble particle of mixtures. RESULTS:There was no significant change in respect of appearance,pH value and content after Fructose injection mixed with cefradine for injection,ribavirin injection,aciclovir for injection,penicillin for injection respectively. Results of study showed good compatible stability of mixtures. The content and pH value were decreased after Fructose injection mixed with levofloxacin hydrochloride for injection and precipitation was found in mixture. CONCLUSION:Fructose injection mixed with cefradine for injection,ribavirin injection,aciclovir for injection,penicillin for injection are stable and reliable. It should be careful to apply the mixture of Fructose injection with levofloxacin hydrochloride for injection.
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OBJECTIVE: To investigate the characteristics and regularity of adverse drug reactions (ADR) occurred in our hospital. METHODS: 286 ADR cases collected from our hospital from Jan. 2007 to Jun. 2009 were analyzed statistically. RESULTS: There were 3 severe ADR cases. 213 ADR cases were caused by anti-infection agents in our hospital (74.48%), followed by 38 ADR cases caused by TCM preparations (13.29%). Main clinical manifestation of ADR cases were lesion of skin and its appendants in 146 cases (44.92%), followed by 62 cases of lesion of digestive system (19.08%). 202 ADR cases were caused by intravenous administration (70.63%). CONCLUSION: Pharmaceutical monitoring and administration system should be established and improved. Great importance should be attached to ADR monitoring to reduced the incidence of ADR in our hospital.
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Objective: To compare the effect of enteral and parenteral nutrition on critically ill patients. Methods: 48 patients with critically ill in ICU were randomly divided into EN group and PN group.The nutritional index and the complication were compared between groups. Results: The levels of Hb,TP and ALB were significantly increased after EN,and the rates of complications in PN group were higher in PN group than that in EN group. Conclusion: Compared to parenteral nutritional support,enteral nutritional support can improve the nutritional condition and have less complications in critically ill patients.